Atlas of Cancer Mortality
Results -- Geographic Patterns for Gallbladder Cancer
Among whites, rates were elevated in portions of the Appalachian region, the
midwestern and north-central regions, and parts of the Southwest, with generally
low rates across the southeastern and far western states. The pattern was more
pronounced among females, whose rates of gallbladder disease, including cancer,
are higher than those of males and reflect the excess risk of gallbladder cancer
in patients with gallstones.52 Despite the rarity of mortality from gallstones,
the geographic patterns have been found to resemble those for gallbladder cancer.
53
The elevated rates of gallstones and gallbladder cancer among Hispanics and
American Indians largely account for the excessive mortality seen in the
southwestern states, while a high incidence of both conditions has been reported
in areas of Appalachia with low socioeconomic levels.
54 The elevated rates in
the northeastern and north-central areas may be related to the concentration of
high-risk ethnic groups from eastern Europe,
52 but further studies are needed.
Among blacks, there was no consistent geographic variation for this rare cancer.
| References |
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| 52. |
Fraumeni JF Jr, Devesa SS, McLaughlin JK, Stanford JL. Biliary tract cancer. In: Schottenfeld D, Fraumeni JF Jr, editors. Cancer epidemiology and prevention. 2nd ed. New York: Oxford University Press; 1996. p. 794-805.
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| 53. |
Mason TJ, Fraumeni JF Jr, Hoover R, Blot WJ. An atlas of mortality from selected diseases. Washington, DC: U.S. Gov. Printing Office; 1981. DHHS Publ. No. (NIH) 81-2397.
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| 54. |
Richardson JD, Scutchfield FD, Proudfoot WH, Benenson AS. Epidemiology of gallbladder disease in an Appalachian community. Health Serv Rep 1973;88:241-6.
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Suggested Citation
Devesa SS, Grauman DG, Blot WJ, Pennello G, Hoover RN, Fraumeni JF Jr. Atlas of cancer
mortality in the United States, 1950-94. Washington, DC: US Govt Print Off; 1999 [NIH Publ No.
(NIH) 99-4564].
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